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Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release
Synaptotagmin 1 (Syt1) is a synaptic vesicle integral membrane protein that regulates neurotransmitter release by activating fast synchronous fusion and suppressing slower asynchronous release. The cytoplasmic C2 domains of Syt1 interact with SNAREs and plasma membrane phospholipids in a Ca(2+)-depe...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4378450/ https://ncbi.nlm.nih.gov/pubmed/25775572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420312112 |
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