Control of neurotransmitter release by an internal gel matrix in synaptic vesicles

Neurotransmitters are stored in synaptic vesicles, where they have been assumed to be in free solution. Here we report that in Torpedo synaptic vesicles, only 5% of the total acetylcholine (ACh) or ATP content is free, and that the rest is adsorbed to an intravesicular proteoglycan matrix. This matr...

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Detalhes bibliográficos
Main Authors: Reigada, David, Díez-Pérez, Ismael, Gorostiza, Pau, Verdaguer, Albert, Gómez de Aranda, Inmaculada, Pineda, Oriol, Vilarrasa, Jaume, Marsal, Jordi, Blasi, Joan, Aleu, Jordi, Solsona, Carles
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152319/
https://ncbi.nlm.nih.gov/pubmed/12629223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0336914100
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