Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. They include the sec...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P. N., Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C. Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O’Hagan, Derek T., Valiante, Nicholas M., Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378396/
https://ncbi.nlm.nih.gov/pubmed/25775551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424924112
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