Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. They include the sec...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P. N., Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C. Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O’Hagan, Derek T., Valiante, Nicholas M., Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378396/
https://ncbi.nlm.nih.gov/pubmed/25775551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424924112
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