Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. They include the sec...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P. N., Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C. Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O’Hagan, Derek T., Valiante, Nicholas M., Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378396/
https://ncbi.nlm.nih.gov/pubmed/25775551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424924112
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