Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. They include the sec...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P. N., Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C. Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O’Hagan, Derek T., Valiante, Nicholas M., Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378396/
https://ncbi.nlm.nih.gov/pubmed/25775551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424924112
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