Prolonged Proteasome Inhibition Cyclically Upregulates Oct3/4 and Nanog Gene Expression, but Reduces Induced Pluripotent Stem Cell Colony Formation

There is ample evidence that the ubiquitin–proteasome system is an important regulator of transcription and its activity is necessary for maintaining pluripotency and promoting cellular reprogramming. Moreover, proteasome activity contributes to maintaining the open chromatin structure found in plur...

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Podrobná bibliografie
Vydáno v:Cell Reprogram
Hlavní autoři: Floyd, Elizabeth Z., Staszkiewicz, Jaroslaw, Power, Rachel A., Kilroy, Gail, Kirk-Ballard, Heather, Barnes, Christian W., Strickler, Karen L., Rim, Jong S., Harkins, Lettie L., Gao, Ru, Kim, Jeong, Eilertsen, Kenneth J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378358/
https://ncbi.nlm.nih.gov/pubmed/25826722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0030
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