Prolonged Proteasome Inhibition Cyclically Upregulates Oct3/4 and Nanog Gene Expression, but Reduces Induced Pluripotent Stem Cell Colony Formation

There is ample evidence that the ubiquitin–proteasome system is an important regulator of transcription and its activity is necessary for maintaining pluripotency and promoting cellular reprogramming. Moreover, proteasome activity contributes to maintaining the open chromatin structure found in plur...

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Bibliografische gegevens
Gepubliceerd in:Cell Reprogram
Hoofdauteurs: Floyd, Elizabeth Z., Staszkiewicz, Jaroslaw, Power, Rachel A., Kilroy, Gail, Kirk-Ballard, Heather, Barnes, Christian W., Strickler, Karen L., Rim, Jong S., Harkins, Lettie L., Gao, Ru, Kim, Jeong, Eilertsen, Kenneth J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2015
Onderwerpen:
Brief Communications
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378358/
https://ncbi.nlm.nih.gov/pubmed/25826722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0030
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