Prolonged Proteasome Inhibition Cyclically Upregulates Oct3/4 and Nanog Gene Expression, but Reduces Induced Pluripotent Stem Cell Colony Formation

There is ample evidence that the ubiquitin–proteasome system is an important regulator of transcription and its activity is necessary for maintaining pluripotency and promoting cellular reprogramming. Moreover, proteasome activity contributes to maintaining the open chromatin structure found in plur...

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Detalhes bibliográficos
Publicado no:Cell Reprogram
Main Authors: Floyd, Elizabeth Z., Staszkiewicz, Jaroslaw, Power, Rachel A., Kilroy, Gail, Kirk-Ballard, Heather, Barnes, Christian W., Strickler, Karen L., Rim, Jong S., Harkins, Lettie L., Gao, Ru, Kim, Jeong, Eilertsen, Kenneth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378358/
https://ncbi.nlm.nih.gov/pubmed/25826722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0030
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