Prolonged Proteasome Inhibition Cyclically Upregulates Oct3/4 and Nanog Gene Expression, but Reduces Induced Pluripotent Stem Cell Colony Formation

There is ample evidence that the ubiquitin–proteasome system is an important regulator of transcription and its activity is necessary for maintaining pluripotency and promoting cellular reprogramming. Moreover, proteasome activity contributes to maintaining the open chromatin structure found in plur...

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Foilsithe in:Cell Reprogram
Main Authors: Floyd, Elizabeth Z., Staszkiewicz, Jaroslaw, Power, Rachel A., Kilroy, Gail, Kirk-Ballard, Heather, Barnes, Christian W., Strickler, Karen L., Rim, Jong S., Harkins, Lettie L., Gao, Ru, Kim, Jeong, Eilertsen, Kenneth J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Mary Ann Liebert, Inc. 2015
Ábhair:
Brief Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378358/
https://ncbi.nlm.nih.gov/pubmed/25826722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0030
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