Protease Activated Receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models

Protease activated receptors (PARs) populate neurons and astrocytes in the brain. The serine protease thrombin, which activates PAR-1 during the first hours after stroke, appears to be associated with the cytotoxicity. Thrombin antagonists and PAR-1 inhibitors have been correlated with reduced cell...

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Pubblicato in:Neuroscience
Autori principali: Rajput, Padmesh S, Lyden, Patrick D, Chen, Bo, Lamb, Jessica A, Pereira, Benedict, Lamb, Alexander, Zhao, Lifu, Lei, I-Farn, Bai, Jilin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377119/
https://ncbi.nlm.nih.gov/pubmed/25261684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.09.038
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