Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia

Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular injury during acute focal ischemia. Stroke was induced in adult Sprague Dawley rats by occluding the middle cerebral artery. I...

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Detalhes bibliográficos
Main Authors: Chen, Bo, Friedman, Beth, Whitney, Michael A., Winkle, Jessica A. Van, Lei, I-Farn, Olson, Emilia S., Cheng, Qun, Pereira, Benedict, Zhao, Lifu, Tsien, Roger Y., Lyden, Patrick D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383068/
https://ncbi.nlm.nih.gov/pubmed/22649241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0369-12.2012
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