Neuroprotection and Vasculoprotection using Genetically Targeted Protease-Ligands

Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully, and therapeutic forms of APC are under development. Engineered recom...

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Detalhes bibliográficos
Publicado no:Brain Res
Main Authors: Rajput, Padmesh S., Lamb, Jessica A., Fernández, Jose Á., Bai, Jilin, Pereira, Benedict R., Lei, I-Farn, Leung, Jennifer, Griffin, John H., Lyden, Patrick D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500472/
https://ncbi.nlm.nih.gov/pubmed/30880117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2019.03.010
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