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GAGA Factor Maintains Nucleosome-Free Regions and Has a Role in RNA Polymerase II Recruitment to Promoters

Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain largely uncharacterized. We assayed the levels of transcriptionally-engaged polymerase using global run-on sequencing (GRO-s...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Fuda, Nicholas J., Guertin, Michael J., Sharma, Sumeet, Danko, Charles G., Martins, André L., Siepel, Adam, Lis, John T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376892/
https://ncbi.nlm.nih.gov/pubmed/25815464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005108
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