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Phosphodiesterase 9A Controls Nitric-oxide Independent cGMP and Hypertrophic Heart Disease
Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces nitric oxide (NO) and natriuretic peptide (NP) coupled signaling, stimulating phosphorylation changes by protein kinase G (PKG). Enhancing cGMP synthesis or blocking its degradation by phosphodiesterase type 5A (PDE...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376609/ https://ncbi.nlm.nih.gov/pubmed/25799991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14332 |
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