Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice

BACKGROUND AND PURPOSE: Neuropathic pain is commonly treated with GABA analogues, steroids or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more COX isozymes but chronic COX inhibition paradoxically increases gastrointestinal inflammation and risk of unwanted cardiovascular e...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Crowe, Molly S, Leishman, Emma, Banks, Matthew L, Gujjar, Ramesh, Mahadevan, Anu, Bradshaw, Heather B, Kinsey, Steven G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376450/
https://ncbi.nlm.nih.gov/pubmed/25393148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13012
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