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Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis

BACKGROUND: Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the enzymatic break down of endocannabinoids locally in the joint. KML29 is an inhi...

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Publicat a:Arthritis Res Ther
Autors principals: Philpott, Holly T., McDougall, Jason J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961325/
https://ncbi.nlm.nih.gov/pubmed/31937359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-2096-3
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