Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias

Aberrant diastolic calcium (Ca) release due to leaky ryanodine receptors (RyR2s) has been recently associated with atrial fibrillation (AF) and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, it remains unclear how diastolic Ca release contributes to the rising of rapid repeti...

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Détails bibliographiques
Publié dans:J Physiol
Auteurs principaux: Lou, Qing, Belevych, Andriy E, Radwański, Przemysław B, Liu, Bin, Kalyanasundaram, Anuradha, Knollmann, Bjorn C, Fedorov, Vadim V, Györke, Sándor
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2015
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376423/
https://ncbi.nlm.nih.gov/pubmed/25384790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.280784
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