Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias

Aberrant diastolic calcium (Ca) release due to leaky ryanodine receptors (RyR2s) has been recently associated with atrial fibrillation (AF) and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, it remains unclear how diastolic Ca release contributes to the rising of rapid repeti...

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Detalles Bibliográficos
Publicado en:J Physiol
Main Authors: Lou, Qing, Belevych, Andriy E, Radwański, Przemysław B, Liu, Bin, Kalyanasundaram, Anuradha, Knollmann, Bjorn C, Fedorov, Vadim V, Györke, Sándor
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376423/
https://ncbi.nlm.nih.gov/pubmed/25384790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.280784
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