Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias

Aberrant diastolic calcium (Ca) release due to leaky ryanodine receptors (RyR2s) has been recently associated with atrial fibrillation (AF) and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, it remains unclear how diastolic Ca release contributes to the rising of rapid repeti...

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Dettagli Bibliografici
Pubblicato in:J Physiol
Autori principali: Lou, Qing, Belevych, Andriy E, Radwański, Przemysław B, Liu, Bin, Kalyanasundaram, Anuradha, Knollmann, Bjorn C, Fedorov, Vadim V, Györke, Sándor
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376423/
https://ncbi.nlm.nih.gov/pubmed/25384790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.280784
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