A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na(+) current

Selective inhibition of the slowly inactivating or late Na(+) current (I(NaL)) in patients with inherited or acquired arrhythmia syndrome may confer therapeutic benefit by reducing the incidence of triggers for arrhythmia and suppressing one component of arrhythmia-promoting cardiac substrates (e.g....

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Yang, Pei-Chi, Song, Yejia, Giles, Wayne R, Horvath, Balazs, Chen-Izu, Ye, Belardinelli, Luiz, Rajamani, Sridharan, Clancy, Colleen E
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376422/
https://ncbi.nlm.nih.gov/pubmed/25545172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.279554
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