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Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we identify a stable pool of impβ at the NPC. A subpopulation...

詳細記述

保存先:
書誌詳細
出版年:eLife
主要な著者: Lowe, Alan R, Tang, Jeffrey H, Yassif, Jaime, Graf, Michael, Huang, William YC, Groves, Jay T, Weis, Karsten, Liphardt, Jan T
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375889/
https://ncbi.nlm.nih.gov/pubmed/25748139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04052
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