Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we identify a stable pool of impβ at the NPC. A subpopulation...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Lowe, Alan R, Tang, Jeffrey H, Yassif, Jaime, Graf, Michael, Huang, William YC, Groves, Jay T, Weis, Karsten, Liphardt, Jan T
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2015
Pynciau:
Biophysics and Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375889/
https://ncbi.nlm.nih.gov/pubmed/25748139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04052
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