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Computational and Functional Analyses of a Small-Molecule Binding Site in ROMK
The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence blood volume and pressure. The discovery of loss-of-function mutations in KCNJ1 underlying renal salt and water wasting and lower blood pressure...
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| 出版年: | Biophys J |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375722/ https://ncbi.nlm.nih.gov/pubmed/25762321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.01.022 |
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