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Computational and Functional Analyses of a Small-Molecule Binding Site in ROMK
The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence blood volume and pressure. The discovery of loss-of-function mutations in KCNJ1 underlying renal salt and water wasting and lower blood pressure...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375722/ https://ncbi.nlm.nih.gov/pubmed/25762321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.01.022 |
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