Computational and Functional Analyses of a Small-Molecule Binding Site in ROMK

The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence blood volume and pressure. The discovery of loss-of-function mutations in KCNJ1 underlying renal salt and water wasting and lower blood pressure...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Swale, Daniel R., Sheehan, Jonathan H., Banerjee, Sreedatta, Husni, Afeef S., Nguyen, Thuy T., Meiler, Jens, Denton, Jerod S.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2015
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375722/
https://ncbi.nlm.nih.gov/pubmed/25762321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.01.022
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