A Soluble Sulfogalactosyl Ceramide Mimic Promotes ΔF508 CFTR Escape from Endoplasmic Reticulum Associated Degradation

AdaSGC binds Hsc70s to inhibit ATPase activity. Using single-turnover assays, adaSGC, a soluble SGC mimic, preferentially inhibited Hsp40-activated Hsc70 ATP hydrolysis (Ki ~ 10 μM) to reduce C-terminal Hsc70-peptide binding and, potentially, chaperone function. ERAD of misfolded ΔF508 CFTR requires...

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Publicat a:Chem Biol
Autors principals: Park, Hyun-Joo, Mylvaganum, Murugesapillai, McPherson, Anne, Fewell, Sheara W., Brodsky, Jeffrey L., Lingwood, Clifford A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375101/
https://ncbi.nlm.nih.gov/pubmed/19389632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.02.014
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