Isoflurane Postconditioning Protects Against Reperfusion Injury by Preventing Mitochondrial Permeability Transition via an Endothelial Nitric Oxide Synthase-dependent Mechanism

BACKGROUND: The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. We addressed this issue using eNOS(-/-) mice. METHODS: In vivo or Langendorff-perfused mouse hearts underwent 30 min of ischemia followed by 2 h of...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Ge, Zhi-Dong, Pravdic, Danijel, Bienengraeber, Martin, Pratt, Phillip F., Auchampach, John A., Gross, Garrett J., Kersten, Judy R., Warltier, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374483/
https://ncbi.nlm.nih.gov/pubmed/19996950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3181c4a607
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