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Failure of isoflurane cardiac preconditioning in obese type 2 diabetic mice involves aberrant regulation of microRNA-21, endothelial nitric oxide synthase, and mitochondrial complex I
BACKGROUND: Diabetes impairs the cardioprotective effect of volatile anesthetics, yet the mechanisms are still murky. We examined the regulatory effect of isoflurane on microRNA-21, endothelial nitric oxide synthase, and mitochondrial respiratory complex I in type II diabetic mice. METHODS: Myocardi...
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| Publicado no: | Anesthesiology |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726897/ https://ncbi.nlm.nih.gov/pubmed/29040168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001926 |
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