Failure of isoflurane cardiac preconditioning in obese type 2 diabetic mice involves aberrant regulation of microRNA-21, endothelial nitric oxide synthase, and mitochondrial complex I

BACKGROUND: Diabetes impairs the cardioprotective effect of volatile anesthetics, yet the mechanisms are still murky. We examined the regulatory effect of isoflurane on microRNA-21, endothelial nitric oxide synthase, and mitochondrial respiratory complex I in type II diabetic mice. METHODS: Myocardi...

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Published in:Anesthesiology
Main Authors: Ge, Zhi-Dong, Li, Yingchuan, Qiao, Shigang, Bai, Xiaowen, Warltier, David C., Kersten, Judy R., Bosnjak, Zeljko J., Liang, Mingyu
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726897/
https://ncbi.nlm.nih.gov/pubmed/29040168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001926
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