MicroRNA-21 mediates isoflurane-induced cardioprotection against ischemia/reperfusion injury via Akt/nitric oxide synthase/mitochondrial permeability transition pore pathway

BACKGROUND: The role of microRNA-21 in isoflurane-induced cardioprotection is unknown. We addressed this issue using microRNA-21 knockout mice and explored the underlying mechanisms. METHODS: C57BL/6 and microRNA-21 knockout mice were echocardiographically examined. Mouse hearts underwent 30 min of...

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Publié dans:Anesthesiology
Auteurs principaux: Qiao, Shigang, Olson, Jessica M., Paterson, Mark, Yan, Yasheng, Zaja, Ivan, Liu, Yanan, Riess, Matthias L., Kersten, Judy R., Liang, Mingyu, Warltier, David C., Bosnjak, Zeljko J., Ge, Zhi-Dong
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573345/
https://ncbi.nlm.nih.gov/pubmed/26259139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000807
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