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MicroRNA-21 mediates isoflurane-induced cardioprotection against ischemia/reperfusion injury via Akt/nitric oxide synthase/mitochondrial permeability transition pore pathway
BACKGROUND: The role of microRNA-21 in isoflurane-induced cardioprotection is unknown. We addressed this issue using microRNA-21 knockout mice and explored the underlying mechanisms. METHODS: C57BL/6 and microRNA-21 knockout mice were echocardiographically examined. Mouse hearts underwent 30 min of...
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| Udgivet i: | Anesthesiology |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4573345/ https://ncbi.nlm.nih.gov/pubmed/26259139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000807 |
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