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Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria
Short application of the volatile anesthetic isoflurane at reperfusion after ischemia exerts strong protection of the heart against injury. Mild depolarization and acidification of the mitochondrial matrix are involved in the protective mechanisms of isoflurane, but the molecular basis for these cha...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653412/ https://ncbi.nlm.nih.gov/pubmed/22796646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.07.003 |
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