Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

[Image: see text] GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential. This is especially the case for the angiotensin receptor subtypes AT1R and AT2R, where a functional negative control has been...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Magnani, Francesca, Pappas, Charalampos G., Crook, Tim, Magafa, Vassiliki, Cordopatis, Paul, Ishiguro, Susumu, Ohta, Naomi, Selent, Jana, Bosnyak, Sanja, Jones, Emma S., Gerothanassis, Ioannis P., Tamura, Masaaki, Widdop, Robert E., Tzakos, Andreas G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374176/
https://ncbi.nlm.nih.gov/pubmed/24787922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500063y
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