Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

[Image: see text] GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential. This is especially the case for the angiotensin receptor subtypes AT1R and AT2R, where a functional negative control has been...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Magnani, Francesca, Pappas, Charalampos G., Crook, Tim, Magafa, Vassiliki, Cordopatis, Paul, Ishiguro, Susumu, Ohta, Naomi, Selent, Jana, Bosnyak, Sanja, Jones, Emma S., Gerothanassis, Ioannis P., Tamura, Masaaki, Widdop, Robert E., Tzakos, Andreas G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374176/
https://ncbi.nlm.nih.gov/pubmed/24787922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500063y
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