Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

[Image: see text] GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential. This is especially the case for the angiotensin receptor subtypes AT1R and AT2R, where a functional negative control has been...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Magnani, Francesca, Pappas, Charalampos G., Crook, Tim, Magafa, Vassiliki, Cordopatis, Paul, Ishiguro, Susumu, Ohta, Naomi, Selent, Jana, Bosnyak, Sanja, Jones, Emma S., Gerothanassis, Ioannis P., Tamura, Masaaki, Widdop, Robert E., Tzakos, Andreas G.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374176/
https://ncbi.nlm.nih.gov/pubmed/24787922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500063y
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