Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

[Image: see text] GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential. This is especially the case for the angiotensin receptor subtypes AT1R and AT2R, where a functional negative control has been...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Magnani, Francesca, Pappas, Charalampos G., Crook, Tim, Magafa, Vassiliki, Cordopatis, Paul, Ishiguro, Susumu, Ohta, Naomi, Selent, Jana, Bosnyak, Sanja, Jones, Emma S., Gerothanassis, Ioannis P., Tamura, Masaaki, Widdop, Robert E., Tzakos, Andreas G.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374176/
https://ncbi.nlm.nih.gov/pubmed/24787922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500063y
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