Design, Syntheses, and Biological Evaluation of 14-Heteroaromatic Substituted Naltrexone Derivatives: Pharmacological Profile Switch from Mu Opioid Receptor Selectivity to Mu/Kappa Opioid Receptor Dual Selectivity

Based on a mu opioid receptor (MOR) homology model and the “isosterism” concept, three generations of 14-heteroaromatically substituted naltrexone derivatives were designed, synthesized, and evaluated as potential MOR selective ligands. The first generation ligands appeared to be MOR selective, wher...

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Publicado en:J Med Chem
Main Authors: Yuan, Yunyun, Zaidi, Saheem A., Elbegdorj, Orgil, Aschenbach, Lindsey C. K., Li, Guo, Stevens, David L., Scoggins, Krista L., Dewey, William L., Selley, Dana E., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373589/
https://ncbi.nlm.nih.gov/pubmed/24144240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4012214
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