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Opioid receptor selectivity profile change via isosterism for 14-O-substitued naltrexone derivatives
Isosterism is commonly used in drug discovery and development to address stability, selectivity, toxicity, pharmacokinetics, and efficacy issues. A series of 14-O-substituted naltrexone derivatives were identified as potent mu opioid receptor (MOR) antagonists with improved selectivity over the kapp...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690547/ https://ncbi.nlm.nih.gov/pubmed/23721804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.027 |
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