Design, Syntheses, and Biological Evaluation of 14-Heteroaromatic Substituted Naltrexone Derivatives: Pharmacological Profile Switch from Mu Opioid Receptor Selectivity to Mu/Kappa Opioid Receptor Dual Selectivity

Based on a mu opioid receptor (MOR) homology model and the “isosterism” concept, three generations of 14-heteroaromatically substituted naltrexone derivatives were designed, synthesized, and evaluated as potential MOR selective ligands. The first generation ligands appeared to be MOR selective, wher...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Yuan, Yunyun, Zaidi, Saheem A., Elbegdorj, Orgil, Aschenbach, Lindsey C. K., Li, Guo, Stevens, David L., Scoggins, Krista L., Dewey, William L., Selley, Dana E., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373589/
https://ncbi.nlm.nih.gov/pubmed/24144240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4012214
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados