Nanoconjugated NAP as a Potent and Periphery Selective Mu Opioid Receptor Modulator To Treat Opioid-Induced Constipation

[Image: see text] Opioids are the mainstay for cancer and noncancer pain management. However, their use is often associated with multiple adverse effects. Among them, the most common and persistent one is probably opioid-induced constipation (OIC). Periphery selective opioid antagonists may alleviat...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Xu, Guoyan G., Zolotarskaya, Olga Yu., Williams, Dwight A., Yuan, Yunyun, Selley, Dana E., Dewey, William L., Akbarali, Hamid I., Yang, Hu, Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238486/
https://ncbi.nlm.nih.gov/pubmed/28105279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00382
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