Chromosome substitution strain assessment of a Huntington’s disease modifier locus

Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human–mouse cross-species functional prior...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mamm Genome
Prif Awduron: Ramos, Eliana Marisa, Kovalenko, Marina, Guide, Jolene R., St. Claire, Jason, Gillis, Tammy, Mysore, Jayalakshmi S., Sequeiros, Jorge, Wheeler, Vanessa C., Alonso, Isabel, MacDonald, Marcy E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372682/
https://ncbi.nlm.nih.gov/pubmed/25645993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-014-9552-9
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