Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β(2)-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis

Objective. IgG aPL against domain I of β(2)-glycoprotein I (β(2)GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG aDI in vivo. In this proof-of-...

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Veröffentlicht in:Rheumatology (Oxford)
Hauptverfasser: Pericleous, Charis, Ruiz-Limón, Patricia, Romay-Penabad, Zurina, Marín, Ana Carrera, Garza-Garcia, Acely, Murfitt, Lucy, Driscoll, Paul C., Latchman, David S., Isenberg, David A., Giles, Ian, Ioannou, Yiannis, Rahman, Anisur, Pierangeli, Silvia S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Basic and Translational Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372675/
https://ncbi.nlm.nih.gov/pubmed/25273993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keu360
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