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Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β(2)-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis
Objective. IgG aPL against domain I of β(2)-glycoprotein I (β(2)GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG aDI in vivo. In this proof-of-...
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| Udgivet i: | Rheumatology (Oxford) |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372675/ https://ncbi.nlm.nih.gov/pubmed/25273993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keu360 |
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