Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β(2)-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis

Objective. IgG aPL against domain I of β(2)-glycoprotein I (β(2)GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG aDI in vivo. In this proof-of-...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Rheumatology (Oxford)
Egile Nagusiak: Pericleous, Charis, Ruiz-Limón, Patricia, Romay-Penabad, Zurina, Marín, Ana Carrera, Garza-Garcia, Acely, Murfitt, Lucy, Driscoll, Paul C., Latchman, David S., Isenberg, David A., Giles, Ian, Ioannou, Yiannis, Rahman, Anisur, Pierangeli, Silvia S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2015
Gaiak:
Basic and Translational Science
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372675/
https://ncbi.nlm.nih.gov/pubmed/25273993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keu360
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