Development of a high yield expression and purification system for Domain I of Beta-2-glycoprotein I for the treatment of APS

BACKGROUND: In this paper we describe a novel method to achieve high yield bacterial expression of a small protein domain with considerable therapeutic potential; Domain I of Beta-2-glycoprotein I (β2GPI). β2GPI is intrinsic to the pathological progression of the Antiphospholipid Syndrome (APS). Pat...

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Vydáno v:BMC Biotechnol
Hlavní autoři: McDonnell, Thomas, Pericleous, Charis, Laurine, Emmanuelle, Tommasi, Rita, Garza-Garcia, Acely, Giles, Ian, Ioannou, Yiannis, Rahman, Anisur
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650279/
https://ncbi.nlm.nih.gov/pubmed/26576675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0222-0
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