BRCA1 Germline Mutations May Be Associated With Reduced Ovarian Reserve

OBJECTIVE: To determine whether BRCA carriers have a decreased ovarian reserve compared to women without BRCA mutations, as BRCA mutations may lead to accelerated oocyte apoptosis due to accumulation of damaged DNA. DESIGN: Cross-sectional study SETTING: Academic tertiary care center PATIENTS: 143 w...

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Detalhes bibliográficos
Publicado no:Fertil Steril
Main Authors: Wang, Erica T., Pisarska, Margareta D., Bresee, Catherine, da Chen, Yii-Der I, Lester, Jenny, Afshar, Yalda, Alexander, Carolyn, Karlan, Beth Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372188/
https://ncbi.nlm.nih.gov/pubmed/25256924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fertnstert.2014.08.014
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