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Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides
[Image: see text] A glutathione S-transferase (GST) catalyzed macrocyclization reaction for peptides up to 40 amino acids in length is reported. GST catalyzes the selective S(N)Ar reaction between an N-terminal glutathione (GSH, γ-Glu-Cys-Gly) tag and a C-terminal perfluoroaryl-modified cysteine on...
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| Publicado no: | Org Lett |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2014
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372082/ https://ncbi.nlm.nih.gov/pubmed/25002256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol501609y |
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