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Convergent Diversity-Oriented Side-Chain Macrocyclization Scan for Unprotected Polypeptides
Here we describe a general synthetic platform for side-chain macrocyclization of an unprotected peptide library based on the S(N)Ar reaction between cysteine thiolates and a new generation of highly reactive perfluoroaromatic small molecule linkers. This strategy enabled us to simultaneously “scan”...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935340/ https://ncbi.nlm.nih.gov/pubmed/24310320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42168f |
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