Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing

The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic material. The final mRNA composition varies based on proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncoprotein with an interactome that we demon...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Selvanathan, Saravana P., Graham, Garrett T., Erkizan, Hayriye V., Dirksen, Uta, Natarajan, Thanemozhi G., Dakic, Aleksandra, Yu, Songtao, Liu, Xuefeng, Paulsen, Michelle T., Ljungman, Mats E., Wu, Cathy H., Lawlor, Elizabeth R., Üren, Aykut, Toretsky, Jeffrey A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371969/
https://ncbi.nlm.nih.gov/pubmed/25737553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500536112
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