Inhibition of the oncogenic fusion protein EWS-FLI1 causes G(2)-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma

Ewing’s sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosoma...

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Publicado no:Sci Signal
Main Authors: Zöllner, Stefan K., Selvanathan, Saravana P., Graham, Garrett T., Commins, Ryan M. T., Hong, Sung Hyeok, Moseley, Eric, Parks, Sydney, Haladyna, Jessica N., Erkizan, Hayriye V., Dirksen, Uta, Hogarty, Michael D., Üren, Aykut, Toretsky, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330879/
https://ncbi.nlm.nih.gov/pubmed/28974650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aam8429
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