Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors

Ewing tumor is driven by the oncogenic EWS-FLI1 fusion protein that functions as an aberrant transcription factor. The identification of EWS-FLI1 protein partners is essential to enhance its vulnerability as a therapeutic target. We utilized phage display library screening against recombinant EWS-FL...

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Huvudupphovsmän: Erkizan, Hayriye V, Scher, Lauren J, Gamble, S Ellen, Barber-Rotenberg, Julie S, Sajwan, Kamal P, Üren, Aykut, Toretsky, Jeffrey A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2011
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233630/
https://ncbi.nlm.nih.gov/pubmed/21926473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.19.17734
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