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Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors
Ewing tumor is driven by the oncogenic EWS-FLI1 fusion protein that functions as an aberrant transcription factor. The identification of EWS-FLI1 protein partners is essential to enhance its vulnerability as a therapeutic target. We utilized phage display library screening against recombinant EWS-FL...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233630/ https://ncbi.nlm.nih.gov/pubmed/21926473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.19.17734 |
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