Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity

Ewing Sarcoma (ES) is associated with a balanced chromosomal translocation that in most cases leads to the expression of the oncogenic fusion protein and transcription factor EWS-FLI1. EWS-FLI1 has been shown to be crucial for ES cell survival and tumor growth. However, its regulation is still enigm...

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Detalhes bibliográficos
Main Authors: Schlottmann, Silke, Erkizan, Hayriye V., Barber-Rotenberg, Julie S., Knights, Chad, Cheema, Amrita, Üren, Aykut, Avantaggiati, Maria L., Toretsky, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2012
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435532/
https://ncbi.nlm.nih.gov/pubmed/22973553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00107
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