Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA Helicase A inhibits Ewing's Sarcoma

Many sarcomas and leukemias carry non-random chromosomal translocations encoding mutant fusion transcription factors that are essential to their molecular pathogenesis. These novel, tumor-specific proteins provides a unique opportunity for the development of highly selective anticancer drugs that ha...

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Detalhes bibliográficos
Main Authors: Erkizan, Hayriye V., Kong, Yali, Merchant, Melinda, Schlottmann, Silke, Barber-Rotenberg, Julie S., Abaan, Ogan D., Chou, Tsu-hang, Dakshanamurthy, Sivanesan, Brown, Milton L., Üren, Aykut, Toretsky, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777681/
https://ncbi.nlm.nih.gov/pubmed/19584866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1983
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