Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing

The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic material. The final mRNA composition varies based on proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncoprotein with an interactome that we demon...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Selvanathan, Saravana P., Graham, Garrett T., Erkizan, Hayriye V., Dirksen, Uta, Natarajan, Thanemozhi G., Dakic, Aleksandra, Yu, Songtao, Liu, Xuefeng, Paulsen, Michelle T., Ljungman, Mats E., Wu, Cathy H., Lawlor, Elizabeth R., Üren, Aykut, Toretsky, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371969/
https://ncbi.nlm.nih.gov/pubmed/25737553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500536112
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